Chen, Sisi Luetje, Charles W. Identification of new Orco antagonists. <p><b>A</b>) Co-application of 100 µM OLC2 inhibits activation of Dmel\Orco by 30 µM OLC12. <b>B</b>) Co-application of 100 µM OLC8 fails to block activation of Dmel\Orco by 30 µM OLC12. <b>C–D</b>) Results of a screen of 20 compounds for Orco antagonism. Responses of Dmel\Orco + Dmel\Or35a to 10 µM OLC12 (EC<sub>25</sub>) (<b>C</b>) or of Dmel\Orco to 30 µM OLC12 (EC<sub>39</sub>) (<b>D</b>) in the presence of 100 µM of each candidate antagonist are presented as a percentage of the average of the two preceding responses to OLC12 alone (mean±SEM, n = 3−6). Sh, sham. <b>E</b>) Structures of Orco antagonists.</p> orco 2012-05-08
    https://plos.figshare.com/articles/figure/_Identification_of_new_Orco_antagonists_/311934
10.1371/journal.pone.0036784.g003