10.1371/journal.pone.0036431.g003 Ketan Marballi Ketan Marballi Dianne Cruz Dianne Cruz Peter Thompson Peter Thompson Consuelo Walss-Bass Consuelo Walss-Bass Levels of Neuregulin 1 (NRG1) cleavage enzymes Presenilin 1 (PS1) and ADAM17 in Brodmann’s Area 9 (BA9). Public Library of Science 2012 neuregulin cleavage enzymes presenilin adam17 2012-05-10 00:07:39 Figure https://plos.figshare.com/articles/figure/_Levels_of_Neuregulin_1_NRG1_cleavage_enzymes_Presenilin_1_PS1_and_ADAM17_in_Brodmann_8217_s_Area_9_BA9_/310459 <p>Values represent relative levels of protein bands, normalized to beta actin. 3A) ADAM17; 3B) BACE1; 3C) ADAM19; 3D) PS1 50 kDa; and 3E) PS1 25 kDa. Controls (•), schizophrenia -SCZ (▪) and bipolar disorder -BPD (▴). 1A) shows levels of ADAM17 to be significantly different between cohorts by ANCOVA [F (2, 15) = 7.166, p = 0.007]. 3D) and E) show PS-1 25 and 50 kDa levels are significantly lower in SCZ by Bonferroni post hoc analyses, compared to controls (p = 0.001) and BPD (p<0.001). Asterisk indicates statistical significance. Graphs are plotted as mean ± standard error.</p>