Postnatal deletion of the <i>Bbs1</i> gene in the mediobasal hypothalamus increases weight gain and adiposity.
Deng-Fu Guo
Huxing Cui
Qihong Zhang
Donald A. Morgan
Daniel R. Thedens
Darryl Nishimura
Justin L. Grobe
Val C. Sheffield
Kamal Rahmouni
10.1371/journal.pgen.1005890.g005
https://plos.figshare.com/articles/figure/Postnatal_deletion_of_the_i_Bbs1_i_gene_in_the_mediobasal_hypothalamus_increases_weight_gain_and_adiposity_/3079327
<p>(A) Cre-mediated recombination in the mediobasal hypothalamus after AAV-Cre microinjection was visualized by td-Tomato expression in Bbs1<sup>fl/fl</sup>/td-Tomato mice. (B) Average weekly body weight changes after bilateral microinjection of AAV-GFP or AAV-Cre into the mediobasal hypothalamus of Bbs1<sup>fl/fl</sup>/td-Tomato mice (n = 8 females per group). (C-E) Representative MRI images (C), body composition (D) and cumulative 5 days food intake (E) of Bbs1<sup>fl/fl</sup>/td-Tomato mice received bilateral injection of AAV-GFP or AAV-Cre (n = 7 females per group). Data are means ± SEM, *P< 0.05 vs. AAV-GFP group.</p>
2016-02-29 07:36:38
Bbs 1 gene
IFT
Ift 88 gene
system causes obesity
pleiotropic autosomal recessive disorder
BBSome Controls Energy Homeostasis
BBS proteins
BBS 1 loss