%0 Figure %A Wu, Kang %A Dong, Dandan %A Fang, Hai %A Levillain, Florence %A Jin, Wen %A Mei, Jian %A Gicquel, Brigitte %A Du, Yanzhi %A Wang, Kankan %A Gao, Qian %A Neyrolles, Olivier %A Zhang, Ji %D 2012 %T Transcriptional importance of STATs, IRF-1, and IRF-7 as supported by cross-signature and cross-module comparisons. %U https://plos.figshare.com/articles/figure/_Transcriptional_importance_of_STATs_IRF_1_and_IRF_7_as_supported_by_cross_signature_and_cross_module_comparisons_/299155 %R 10.1371/journal.pone.0038367.g005 %2 https://plos.figshare.com/ndownloader/files/628680 %K irf-7 %K supported %K cross-signature %K cross-module %X

(A) qRT-PCR validation of IFNB1 induction. Data were from samples as in Figure 4. ** for P-value<0.01. (B) Gene overlap of the THP1r2Mtb-induced signature and an active pulmonary TB (PTB) signature [13]. (C) Regulatory/TFBS enrichment analysis in promoter regions of the active PTB signature in the form of PWM. (D) Gene overlap analysis of predefined modules and the THP1r2Mtb-induced signature. Only those modules with more than 10% of genes (represented by the proportion of black area in the pie) presented in the THP1r2Mtb-induced signature were displayed. Functional interpretations of modules through literature profiling [15] were indicated at lower panel. (E) Regulatory/TFBS enrichment analysis of module M3.1.

%I PLOS ONE