%0 Figure %A Lee, Nathan V. %A E. Lira, Maruja %A Pavlicek, Adam %A Ye, Jingjing %A Buckman, Dana %A Bagrodia, Shubha %A P. Srinivasa, Sreesha %A Zhao, Yongjun %A Aparicio, Samuel %A A. Rejto, Paul %A Christensen, James G. %A A. Ching, Keith %D 2012 %T Copy Number Variation (CNV) indicates that BRAF is amplified and bisected in resistant clones. %U https://plos.figshare.com/articles/figure/_Copy_Number_Variation_CNV_indicates_that_BRAF_is_amplified_and_bisected_in_resistant_clones_/290223 %R 10.1371/journal.pone.0039653.g003 %2 https://plos.figshare.com/ndownloader/files/619748 %K indicates %K braf %K amplified %K bisected %K resistant %X

Relative to GTL16, CNV analysis identifies a region of increased copy number at 7q34, with a breakpoint within the BRAF locus in GTL16R1 and GTL16R3. In conjunction with Affymetrix expression analysis, genes within the amplified regions are coordinately over-expressed (indicated in red) normalized to GTL16. Expression of the BRAF transcript is increased over GTL16.

%I PLOS ONE