10.1371/journal.pone.0147948.g004
Christina S. Kamma-Lorger
Christina
S. Kamma-Lorger
Christian Pinali
Christian
Pinali
Juan Carlos Martínez
Juan
Carlos Martínez
Jon Harris
Jon
Harris
Robert D. Young
Robert D.
Young
Cecilie Bredrup
Cecilie
Bredrup
Eva Crosas
Eva
Crosas
Marc Malfois
Marc
Malfois
Eyvind Rødahl
Eyvind
Rødahl
Keith M. Meek
Keith
M. Meek
Carlo Knupp
Carlo
Knupp
Theoretical representation explaining protein aggregation in stromal “spaces”.
Public Library of Science
2016
homology modelling techniques
diameter
Corneal CSCD specimens
collagen
cornea
tomography
Congenital Stromal Corneal Dystrophy
protein
DCN
extracellular matrix
fibrillar
role
SAXS
fibril
electron
Decorin Core Protein
2016-02-01 20:57:20
Figure
https://plos.figshare.com/articles/figure/Theoretical_representation_explaining_protein_aggregation_in_stromal_spaces_/2761633
<p>The mutation in Decorin in the case of CSCD did not affect the protein’s ability to form dimers, but prevented it from interacting with collagen and caused it to subsequently aggregate in lamellar gaps in the diseased stroma. The aggregated molecules formed anti-parallel associations. The regions with the protein cores are unstained and invisible, whereas the two fold axes are where the red diamonds are.</p>