10.1371/journal.pone.0147948.g004 Christina S. Kamma-Lorger Christina S. Kamma-Lorger Christian Pinali Christian Pinali Juan Carlos Martínez Juan Carlos Martínez Jon Harris Jon Harris Robert D. Young Robert D. Young Cecilie Bredrup Cecilie Bredrup Eva Crosas Eva Crosas Marc Malfois Marc Malfois Eyvind Rødahl Eyvind Rødahl Keith M. Meek Keith M. Meek Carlo Knupp Carlo Knupp Theoretical representation explaining protein aggregation in stromal “spaces”. Public Library of Science 2016 homology modelling techniques diameter Corneal CSCD specimens collagen cornea tomography Congenital Stromal Corneal Dystrophy protein DCN extracellular matrix fibrillar role SAXS fibril electron Decorin Core Protein 2016-02-01 20:57:20 Figure https://plos.figshare.com/articles/figure/Theoretical_representation_explaining_protein_aggregation_in_stromal_spaces_/2761633 <p>The mutation in Decorin in the case of CSCD did not affect the protein’s ability to form dimers, but prevented it from interacting with collagen and caused it to subsequently aggregate in lamellar gaps in the diseased stroma. The aggregated molecules formed anti-parallel associations. The regions with the protein cores are unstained and invisible, whereas the two fold axes are where the red diamonds are.</p>