Sch B inhibits Dox induced NADPH oxidase subunits. Rajarajan A. Thandavarayan Vijayasree V. Giridharan Somasundaram Arumugam Kenji Suzuki Kam Ming Ko Prasanna Krishnamurthy Kenichi Watanabe Tetsuya Konishi 10.1371/journal.pone.0119214.g008 https://plos.figshare.com/articles/figure/Sch_B_inhibits_Dox_induced_NADPH_oxidase_subunits_/2674039 <p>(A–D) Representative Western immunoblots and densitometry analysis using Scion image software for p47phox, p67phox and gp91phox in group N, group V and Sch B treated mice; Blots were normalized against GAPDH. Each bar represents means ± S.E. (n = 3–5). **<i>P <</i> 0.01 vs. group N mice; <sup>#</sup><i>P <</i> 0.05 and <sup>##</sup><i>P <</i> 0.01 vs. group V mice.</p> 2015-03-05 15:01:36 NADPH oxidase subunits cardiomyocyte DNA damage Sch B treatment mitogen kinase 2 levels LV proinflammatory cytokines Doxorubicin Induced Cardiac Dysfunction Sch B expression Sch B treatment mice Schisandrin B reactive oxygen species IP MAPK