Comparison of experimental patterns of antigenicity, predicted antigenicity, and conformational dynamics, for FC27 (left) and 3D7 (right) MSP2.
Christopher A. MacRaild
Milan Zachrdla
Dean Andrew
Bankala Krishnarjuna
Jiří Nováček
Lukáš Žídek
Vladimír Sklenář
Jack S. Richards
James G. Beeson
Robin F. Anders
Raymond S. Norton
10.1371/journal.pone.0119899.g007
https://plos.figshare.com/articles/figure/Comparison_of_experimental_patterns_of_antigenicity_predicted_antigenicity_and_conformational_dynamics_for_FC27_left_and_3D7_right_MSP2_/2674000
<p>A. Antigenicity profiles of MSP2 inferred from experimental immunisation of mice (black) and rabbits (red) are plotted against the sequence. Black bars (top) denote the location of epitopes of a panel of monoclonal antibodies to MSP2. B. Conformational flexibility of MSP2 as measured by the spectral density functions derived from the <sup>15</sup>N relaxation data. Spectral density functions are plotted at zero frequency (black line) and at the <sup>15</sup>N Larmor frequency (red line). C. Antigenicity of MSP2 as predicated using BepiPred [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119899#pone.0119899.ref060" target="_blank">60</a>] (red, right axis) and the method of Kolaskar and Tongaonkar [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119899#pone.0119899.ref061" target="_blank">61</a>] (black, left axis). The threshold for epitope prediction for both methods is denoted by the grey line.</p>
2015-03-05 15:07:10
malaria
vaccine
MSP 2. Regions
region
FC
Disordered Malaria Antigen Merozoite Surface Protein 2 Merozoite surface protein 2
NMR relaxation data
MSP 2
Recombinant MSP 2