%0 Figure %A T. Woods, Lucas %A M. Camden, Jean %A G. El-Sayed, Farid %A G. Khalafalla, Mahmoud %A J. Petris, Michael %A Erb, Laurie %A Weisman, Gary A. %D 2015 %T TGF-β R1 inhibitors SB431542 and GW788388 attenuate duct ligation-induced upregulation of fibrosis markers. %U https://plos.figshare.com/articles/figure/TGF_R1_inhibitors_SB431542_and_GW788388_attenuate_duct_ligation_induced_upregulation_of_fibrosis_markers_/2669503 %R 10.1371/journal.pone.0123641.g007 %2 https://plos.figshare.com/ndownloader/files/4332268 %K GW %K 28 day duct deligation %K fibrosis markers collagen 1 %K ductal cells upregulation %K Smad family transcription factors %K SB %K acinar cells %K 7 day SMG duct ligation %K TGF %K duct ligation %X

RT-PCR analysis of 7 day ligated and contralateral unligated control SMGs shows significant attenuation of 7 day duct ligation-induced collagen 1 and fibronectin mRNA upregulation in mice treated with either SB431542 (20 mg/kg mouse weight) or GW788388 (2 mg/kg mouse weight), as compared to DMSO-treated controls. Data represent means ± S.E.M. (n = 6 for DMSO, n = 6 for SB431542, n = 5 for GW788388), where *P<0.05 and ***P<0.001 indicate significant differences in mRNA expression, as compared to DMSO-treated controls.

%I PLOS ONE