10.1371/journal.pone.0147552.g003
Maciej Wilk
Maciej
Wilk
Roland Hessler
Roland
Hessler
Kenneth Mugridge
Kenneth
Mugridge
Claude Jolly
Claude
Jolly
Michael Fehr
Michael
Fehr
Thomas Lenarz
Thomas
Lenarz
Verena Scheper
Verena
Scheper
Dexamethasone release rates from guinea pig electrode measured in vitro.
Public Library of Science
2016
round window membrane approach
implantation impedance levels
round window niche
DEX
Dexamethasone Eluting Electrode BackgroundThe efficiency
attenuating electrode impedance
CI electrode arrays
electrode array
tissue growth
guinea pig cochleae
auditory brainstem responses
Fibrous Tissue Growth
2016-02-03 21:50:15
Figure
https://plos.figshare.com/articles/figure/Dexamethasone_release_rates_from_guinea_pig_electrode_measured_in_vitro_/2603887
<p>The first 4 mm of the electrode array were immersed into 1 ml of saline solution at 37°C. The saline solution was periodically sampled and DEX concentrations were measured by HPLC-MS (Agilent 1200 HPLC coupled with a Bruker MicrOTOF-Q II MS-detector). Representative release profile measurements for the 1% (red squares) and 10% (blue triangles) DEX loaded electrodes are shown. Over the experimental time period (91 days) the average release rate of DEX from the 1% and 10% loaded electrodes was estimated to be in the order of 16 ng/day and 49 ng/day respectively. DEX release rates were higher in the initial elution period (e.g. average over the first five days: 62 ng/day and 166 ng/day respectively for the 1% and 10% electrodes) with a slow decay over time.</p>