%0 Generic %A S. Mittra, Erik %A Koglin, Norman %A Mosci, Camila %A Kumar, Meena %A Hoehne, Aileen %A Visith Keu, Khun %A H. Iagaru, Andrei %A Mueller, Andre %A Berndt, Mathias %A Bullich, Santiago %A Friebe, Matthias %A Schmitt-Willich, Heribert %A Gekeler, Volker %A M. Fels, Lüder %A Bacher-Stier, Claudia %A Moon, Dae Hyuk %A Chin, Frederick T. %A W. Stephens, Andrew %A Dinkelborg, Ludger M. %A Gambhir, Sanjiv S. %D 2016 %T Comparison of 18F-FSPG, 18F-FET and 18F-FDG uptake in rat GS9L brain tumors, healthy brain and blood at approximately 1 hr post injection. %U https://plos.figshare.com/articles/dataset/Comparison_of_18F_FSPG_18F_FET_and_18F_FDG_uptake_in_rat_GS9L_brain_tumors_healthy_brain_and_blood_at_approximately_1_hr_post_injection_/2586634 %R 10.1371/journal.pone.0148628.t001 %2 https://plos.figshare.com/ndownloader/files/4233091 %K measure xC %K imaging orthotopic brain tumors %K ratio %K orthotopic brain tumors %K safety parameters %K metastatic brain cancer %K intracranial malignancies %K tumor uptake %K brain metastases %K future studies %K subject %K GS 9L model %K 300 MBq %K Fischer rats %K glutamate analogue %K tumor visualization %K brain tumors %K age 50.4 years %K Clinical Evaluation %K animal study %K CT %K Positron Emission Tomography %K animal model.Conclusions 18F %K scan %K background signal %K Pilot Preclinical %K GS 9L glioblastoma cells %K intracranial malignancies.Experimental DesignFor %K brain tumor %K transporter activity %K pilot study %K NCT %K novel PET %X

The tracer uptake was measured ex vivo and is shown as % ID/g values with standard deviation and ranges. Tumor-to-normal brain (T/brain) and tumor-to-blood ratios (T/blood) were derived from the respective mean values.

%I PLOS ONE