10.1371/journal.pone.0149491.g003 Natalia Guerra-Pérez Natalia Guerra-Pérez Meropi Aravantinou Meropi Aravantinou Filippo Veglia Filippo Veglia Diana Goode Diana Goode Rosaline Truong Rosaline Truong Nina Derby Nina Derby James Blanchard James Blanchard Brooke Grasperge Brooke Grasperge Agegnehu Gettie Agegnehu Gettie Melissa Robbiani Melissa Robbiani Elena Martinelli Elena Martinelli HSV-2 induces a pro-inflammatory environment. Public Library of Science 2016 macaque Rectal HSV -2 Infection May CCR SIVmac 239wt plasma HSV -2 Vaginal HSV -2 infection increases 3 animals co-infected SIVmac 239wt rectal infection Rectal SIV Acquisition SHIV rectal SIV infection HIV acquisition SIVmac 239wt infection rectal HSV -2 infection rectal SIVmac 239 wild-type blood CD 4 counts 2016-02-17 12:11:18 Figure https://plos.figshare.com/articles/figure/HSV_2_induces_a_pro_inflammatory_environment_/2359639 <p>The concentration of cytokines and chemokines significantly modulated by HSV-2 infection in plasma 3 weeks post-HSV-2 infection (time of SIVmac239wt challenge) are shown for the animals that acquired HSV-2 or SIVΔNef infection compared to those that remained uninfected (Uninf). Bars represent mean±SEM. Significant p values from Mann-Whitney test are shown (α<0.05).</p>