%0 Figure %A Changrob, Siriruk %A Wang, Bo %A Han, Jin-Hee %A Lee, Seong-Kyun %A Htut Nyunt, Myat %A Lim, Chae Seung %A Tsuboi, Takafumi %A Chootong, Patchanee %A Han, Eun-Taek %D 2016 %T Levels of naturally acquired antibody against PvRAMA in P. vivax-exposed individuals. %U https://plos.figshare.com/articles/figure/Levels_of_naturally_acquired_antibody_against_PvRAMA_in_i_P_i_i_vivax_i_exposed_individuals_/2356327 %R 10.1371/journal.pone.0148723.g003 %2 https://plos.figshare.com/ndownloader/files/3995068 %K GPI %K IgG 3 isotypes %K T cell responses %K IFN %K IgG 3 %K 12 months %K induction %K Plasmodium vivax RAMA %K PvRAMA antigen %K antibody %K PBMC %K vivax infection %K immunogenicity %K IL %K memory T cells %X

(A). The level of PvRAMA and PvMSP1-19-specific total IgG in 77 serum samples from P. vivax-exposed individuals, including 27 samples from the acute phase, 21 samples collected 3 months after recovery, 15 samples collected 9 months after recovery, and 14 samples collected 12 months after recovery, plus 32 serum samples from malaria-naïve individuals. (B). Stability of the antibody response against PvRAMA in a group of recovered patients at different time points (acute phase, 3 months, 9 months and 12 months of recovery). The cutoff value for seropositivity was an OD greater than the mean plus two SD of that for the naïve controls (PvRAMA cutoff OD = 0.071, PvMSP1-19 cutoff OD = 0.101). Antibody levels in different groups were compared using the Mann–Whitney U test.

%I PLOS ONE