Cogen, Anna L. L. Walker, Stephen Roberts, Chrissy H. A. Hagge, Deanna D. Neupane, Kapil Khadge, Saraswoti N. J. Lockwood, Diana Human beta-defensin 3 is up-regulated in the skin of leprosy patients with Type 1 reactions. <p>Skin biopsies from leprosy patients with Type 1 reactions (T1Rs) and leprosy patients without T1Rs (Controls) were assessed for their expression hBD2 and hBD3 as measured by qPCR. The skin of patients with T1Rs showed non-significantly elevated (A) hBD2 expression and a significant increase in (B) hBD3 expression. (C) Cellular infiltration in the T1Rs and the Controls show no significant differences. For the statistical analyses, values were first converted to a Gaussian distribution by taking their square and subsequently an un-paired t-test was performed. *p<0.05 is considered significant.</p> beta-defensin;up-regulated;leprosy;patients 2013-02-19
    https://plos.figshare.com/articles/figure/_Human_beta_defensin_3_is_up_regulated_in_the_skin_of_leprosy_patients_with_Type_1_reactions_/219925
10.1371/journal.pntd.0001869.g001