Propensity of pneumococcal serotypes for invasive disease (meningitis) given carriage, relative to other serotypes or -groups.
Judith E. Mueller
Seydou Yaro
Macaire S. Ouédraogo
Natalia Levina
Berthe-Marie Njanpop-Lafourcade
Haoua Tall
Régina S. Idohou
Oumarou Sanou
Sita S. Kroman
Aly Drabo
Boubacar Nacro
Athanase Millogo
Mark van der Linden
Bradford D. Gessner
10.1371/journal.pone.0052464.t003
https://plos.figshare.com/articles/dataset/_Propensity_of_pneumococcal_serotypes_for_invasive_disease_meningitis_given_carriage_relative_to_other_serotypes_or_groups_/192995
<p>The invasiveness index was calculated using all cases of pneumococcal meningitis with serotype or -group information identified during the dry season months of 2007–2009 (N = 113) and pneumococcal carriage (N = 166) identified in Bobo-Dioulasso, Burkina Faso, March 2007– February 2009. Serotyping was based on cerebrospinal fluid polymerase chain reaction testing <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052464#pone.0052464-NjanpopLafourcade1" target="_blank">[8]</a> or Quellung reaction on invasive isolates; and on Quellung reaction for carriage isolates. The table reports serotypes that were found in at least one meningitis case, found in at least three carriers, or included in 10- or 13-valent pneumococcal conjugate vaccines.</p>*<p>Discrimination within the serogroup or between serotypes not possible for some meningitis cases due to PCR algorithm.</p>†<p>PCR serotyping on invasive isolates or CSF cannot discriminate between 12A/B/F, while Quellung typing of carriage isolates identified 12F only.</p>‡<p>Cornfield estimation of the confidence interval possible only under certain conditions.</p>
2012-12-20 00:49:55
pneumococcal
serotypes
invasive