SPX has little effect on changes in the pancreatic islets in IL-10-deficient mice.
Koro Gotoh
Megumi Inoue
Kentaro Shiraishi
Takayuki Masaki
Seiichi Chiba
Kimihiko Mitsutomi
Takanobu Shimasaki
Hisae Ando
Kansuke Fujiwara
Isao Katsuragi
Tetsuya Kakuma
Masataka Seike
Toshiie Sakata
Hironobu Yoshimatsu
10.1371/journal.pone.0053154.g006
https://plos.figshare.com/articles/figure/_SPX_has_little_effect_on_changes_in_the_pancreatic_islets_in_IL_10_deficient_mice_/187256
<p>(<b>A</b>) Representative images of insulin staining (left), Mallory-Azan staining (middle), and α-SMA staining (right) in pancreas sections from each group. Scale bar = 100 µm. (<b>B−F</b>) Insulin-staining area in the pancreas (<b>B</b>), intra-islet fibrosis area (<b>C</b>) and intra-lobular fibrosis area (<b>D</b>), hydroxyproline content (<b>E</b>) and α-SMA-positive cells (<b>F</b>) in each group (<i>n</i> = 6). *<i>P</i><0.05 vs. the Sham group (wild-type or IL-10KO mice), <sup>#</sup><i>P</i><0.05 vs. SPX mice (wild-type). Treatment groups: Sham, fed a HF diet, given serum albumin and sham-operated; SPX, fed a HF diet, given serum albumin, and splenectomized; SPX+IL-10, fed a HF diet, given recombinant mouse IL-10 and splenectomized. Wild-type, wild-type mice; IL-10KO, IL-10-deficient mice.</p>
2013-02-19 17:54:34
changes
pancreatic
islets
il-10-deficient