Nanni, Patrizia
Gatta, Valentina
Menotti, Laura
De Giovanni, Carla
Ianzano, Marianna
Palladini, Arianna
Grosso, Valentina
Dall'Ora, Massimiliano
Croci, Stefania
Nicoletti, Giordano
Landuzzi, Lorena
Iezzi, Manuela
Campadelli-Fiume, Gabriella
Lollini, Pier-Luigi
Therapy with R-LM249 of systemic metastases induced by the i.v. injection of human breast carcinoma cell line MDA-MB-453.
<p>R-LM249 was administered i.p. at 10<sup>8</sup> pfu dose (4 weekly injections) to groups of 9–10 Rag2<sup>−/−</sup>;Il2rg<sup>−/−</sup> mice. (<b>A, C, E</b>) incidence of macroscopic metastases in the indicated organs, as determined at necropsy; (<b>B, D, F</b>) total metastatic burden (mean + SEM) in organs as quantified by human centromeric DNA qPCR. Statistical analysis of differences: panel <b>A</b>, p<0.0001 at Fisher's exact test; panel <b>B</b>, p = 0.0004 at both Student's <i>t</i> and non-parametric Wilcoxon rank sum tests; panel <b>C</b>, p = 0.07 at Fisher's exact test; panel <b>D</b>, p = 0.056 at Student's <i>t</i> test and p = 0.03 at non-parametric Wilcoxon rank sum test.</p>
r-lm249;systemic;metastases;induced;injection;carcinoma
2013-01-31
https://plos.figshare.com/articles/_Therapy_with_R_LM249_of_systemic_metastases_induced_by_the_i_v_injection_of_human_breast_carcinoma_cell_line_MDA_MB_453_/168640

10.1371/journal.ppat.1003155.g005