Partial CLUSTAL 2.1 multiple sequence alignment of publicly available <i>Brugia malayi</i> (Bm1_48165), <i>Homo sapiens</i> (<i>Hs</i>SAH), <i>Saccharomyces cerevisiae</i> (<i>Sc</i>SAH), and our cloned <i>Brugia malayi</i> (<i>Bm</i>SAH) S-adenosyl homocysteinases, showing the “insert” missing from the publicly available nematode protein sequence.
Elizabeth Bilsland
Daniel M. Bean
Eileen Devaney
Stephen G. Oliver
10.1371/journal.pntd.0004401.g002
https://plos.figshare.com/articles/figure/_Partial_CLUSTAL_2_1_multiple_sequence_alignment_of_publicly_available_Brugia_malayi_Bm1_48165_Homo_sapiens_Hs_SAH_Saccharomyces_cerevisiae_Sc_SAH_and_our_cloned_Brugia_malayi_Bm_SAH_S_adenosyl_homocysteinases_showing_the_insert_missing_from_the_publicly_/1642733
<p>The absence of the 27 amino acids in the publicly available <i>Brugia</i> sequence (Bm1_48165) could indicate a splice variant of the enzyme or simply a problem with the genome assembly.</p>
2016-01-28 12:42:23
World Health Organization
filarial
compound
aid antihelmintic drug development
Brugia malayi drug targets
contracting lymphatic filariasis
complement yeast deletions
Identify Novel Compounds
Brugia malayi BackgroundLymphatic filariasis
strain
parasite enzymes
worms Wuchereria bancrofti
Brugia malayi enzymes