Sliding window correlation (SWC) to identify GO terms associated with serum neutralization titers.
Richard C. Laughlin
Kenneth L. Drake
John C. Morrill
L. Garry Adams
10.1371/journal.pone.0147027.g008
https://plos.figshare.com/articles/figure/_Sliding_window_correlation_SWC_to_identify_GO_terms_associated_with_serum_neutralization_titers_/1638987
<p>(<b>A</b>) Immunologically important GO terms correlated with log10(PRNT<sub>80</sub>) listed by time window with associated p-value indicated significance of correlation. (<b>B</b>) Correlated GO terms plotted as log10(PRNT<sub>80</sub>) vs Normalized GO term DBGGA Bayesian z-scores. The GO term <i>Viral life cycle</i> had a negative correlation with seroconversion at the windowed time points –6, –5, and –4 pSN (upper panel), while <i>Positive regulation of T cell cytokine production</i> shows a positive correlation with seroconversion at the windowed time points –4, –3, and –2 pSN (lower panel).</p>
2016-01-28 12:37:42
arMP -12.
RVF
Correlative Gene Expression
negative-stranded RNA virus
time course RNAs
Rift Valley fever
serum neutralizing antibody responses
Additional bioinformatic analyses
vaccine
vaccination
RVFV
Rift Valley Fever Vaccinates Rift Valley fever Virus
immunity
21 days
vector-borne zoonotic disease