%0 Figure %A Landais, Elise %A Huang, Xiayu %A Havenar-Daughton, Colin %A Murrell, Ben %A A. Price, Matt %A Wickramasinghe, Lalinda %A Ramos, Alejandra %A B. Bian, Charoan %A Simek, Melissa %A Allen, Susan %A Karita, Etienne %A Kilembe, William %A Lakhi, Shabir %A Inambao, Mubiana %A Kamali, Anatoli %A J. Sanders, Eduard %A Anzala, Omu %A Edward, Vinodh %A Bekker, Linda-Gail %A Tang, Jianming %A Gilmour, Jill %A L. Kosakovsky-Pond, Sergei %A Phung, Pham %A Wrin, Terri %A Crotty, Shane %A Godzik, Adam %A Poignard, Pascal %D 2016 %T Correlation between clinical parameters and development of broadly neutralizing antibody responses. %U https://plos.figshare.com/articles/figure/_Correlation_between_clinical_parameters_and_development_of_broadly_neutralizing_antibody_responses_/1637681 %R 10.1371/journal.ppat.1005369.g002 %2 https://plos.figshare.com/ndownloader/files/2627672 %K neutralization breadth %K IAVI Protocol C program %K bnAb responses %K vaccine %K infection %K plasma IgG levels %K CD 4 T cell counts %K hiv %K neutralizing antibody responses %X

(A) Bivariate and multivariable GLM correlation analyses between the listed variables, and the best neutralization score for the M48+ subset of Protocol C participants. Number of participants in each subgroup (N) is indicated. Estimated coefficients (EstCoef), p-values, q-values, odd ratios (ExpEst) upper (U95) and lower (L95) values of the 95% confidence interval are indicated. P-values are color coded as follows: 0.01< p-value < 0.05, in green; 0.001< p-value < 0.01, in yellow; 2E-16 < p-value <0.001, in red. Q-values below 0.1 are indicated in bold. (B) Kaplan Meier curves recording the time for Protocol C neutralizers (best neutralization score ≥ 0.5, N = 157) within the indicated subgroups to reach a neutralization score ≥ 0.5. Log-Rank test p-values are indicated. DC: Discordant couple, OHS: Other Heterosexual transmission, HSM: Women to Men Heterosexual transmission, HSW: Men to Women Heterosexual transmission, MSM: Men who have Sex with Men.

%I PLOS Pathogens