%0 Figure %A T. Gustafson, Carl %A Boakye-Agyeman, Felix %A L. Brinkman, Cassandra %A Reid, Joel M. %A Patel, Robin %A Bajzer, Zeljko %A Dadsetan, Mahrokh %A Yaszemski, Michael J. %D 2016 %T Biocompatibility and swelling ratio of OPF/SMA hydrogel discs. %U https://plos.figshare.com/articles/figure/_Biocompatibility_and_swelling_ratio_of_OPF_SMA_hydrogel_discs_/1637153 %R 10.1371/journal.pone.0146401.g002 %2 https://plos.figshare.com/ndownloader/files/2626906 %K research group %K antibiotic therapy %K stock vancomycin %K dosing schedules %K side effects %K antimicrobial agents %K antimicrobial activity %K vancomycin release %K opf %K antimicrobial compounds %K Patient compliance %K 6 hours %K combat SSI %K Vancomycin release kinetics %K 500 μ g drug %K loading mechanism %K copolymer %K mg hydrogel %K biocompatible hydrogel matrices %K 24 hours %K wound antibiotic treatment %K Controlled Delivery %K antibiotic delivery vehicle %K patient recovery time %K Charged Hydrogels Surgical site infection %K release formulations %K site infection %X

Cell viability of MC3T3-E1 (A) and W20-17 (B) cells incubated with OPF/SMA copolymer hydrogel films. Cell viability determined after 72 hour incubation in the presence of OPF/SMA hydrogel discs. Viability assessed with CellTiter Glo 96 MTS viability assay (ProMega). Hydrogels were directly placed into the dishes and were in contact with cell cultures during the incubation time. Hydrogel discs (as described) were swollen in either, double distilled water, DPBS, or a solution of vancomycin hydrochloride (400 μg/mL) in double distilled water. The hydrogels were dried, weighed, then swollen again and weighed again. Swelling ratio (SR) calculated as described in Materials and Methods. Error bars represent +/- one standard deviation, N = 3 in all groups. (*) indicates a statistically significant difference (p<0.05) between DPBS and double distilled water groups.

%I PLOS ONE