The effects of MEHP exposure on interaction of RelB/p52 with the <i>CRH/COX-2</i> gene promoters.
Ximi K. Wang
Monica Agarwal
Nataliya Parobchak
Alex Rosen
Anna M. Vetrano
Aarthi Srinivasan
Bingbing Wang
Todd Rosen
10.1371/journal.pone.0147013.g003
https://plos.figshare.com/articles/figure/_The_effects_of_MEHP_exposure_on_interaction_of_RelB_p52_with_the_CRH_COX_2_gene_promoters_/1635617
<p>Term cytotrophoblast were exposed to MEHP for 24 hrs at concentrations as indicated. ChIP assays were performed to determine occupancy of RelB/p52 at <i>CRH</i> (<b>A</b>) and <i>COX-2</i> (<b>B</b>), and also occupancy of RelA at the <i>CRH</i> (<b>C</b>) and <i>COX-2</i> (<b>D</b>) gene promoter. Fold enrichment was derived with normalization to a human DNA a satellite, a non-coding DNA sequence to which no transcriptional factors should bind. Rabbit IgG was used as a non-specific control. The bars indicate the average of fold enrichment with error bars representing the standard deviation from three independent experiments. * p < 0.01.</p>
2016-01-18 15:12:56
Human Placenta Women
phthalate metabolites
gene activity
crh
mehp
preterm birth
mechanism
cox
relb
Protein abundance
pathway