A model of the interaction of DR5026 with a bacterial membrane.
Natalya Panova
Eva Zborníková
Ondřej Šimák
Radek Pohl
Milan Kolar
Katerina Bogdanova
Renata Vecerova
Gabriela Seydlová
Radovan Fiser
Romana Hadravová
Hana Šanderová
Dragana Vítovská
Michaela Šiková
Tomáš Látal
Petra Lovecká
Ivan Barvík
Libor Krásný
Dominik Rejman
10.1371/journal.pone.0145918.g009
https://plos.figshare.com/articles/figure/_A_model_of_the_interaction_of_DR5026_with_a_bacterial_membrane_/1630221
<p>The final state of MD simulation after 55 ns shows <b>DR5026</b> molecules penetrated into the phospholipid bilayer. The nitrogen atoms from the iminosugar modules of <b>DR5026</b> are highlighted as blue spheres. Phosphorus atoms of the phospholipid bilayer (PB) are depicted as yellow/red spheres. For clarity, almost all atoms of the PB are hidden.</p>
2016-01-05 14:53:52
strain
transepithelial transport
Bactericidal Lipophosphonoxins
cell disintegration
Ames test
bactericidal concentrations LPPOs
compound
plasmatic membrane
acidic environment