10.1371/journal.pone.0142615.g004
Sarah N. Le
Sarah
N. Le
Benjamin T. Porebski
Benjamin
T. Porebski
Julia McCoey
Julia
McCoey
James Fodor
James
Fodor
Blake Riley
Blake
Riley
Marlena Godlewska
Marlena
Godlewska
Monika Góra
Monika
Góra
Barbara Czarnocka
Barbara
Czarnocka
J Paul Banga
J
Paul Banga
David E. Hoke
David
E. Hoke
Itamar Kass
Itamar
Kass
Ashley M. Buckle
Ashley
M. Buckle
Mapping epitopes onto the cis TPO dimer.
Public Library of Science
2015
Autoantigenicity Thyroid peroxidase
TPO structure
Thyroid hormones
apical membrane
TPO dimer
dimer organisation
immunodominant regions
sequence features
20 years
surface regions
dimer interface
domain rearrangements
Oligomeric State
mpo
enzyme function
Epitope mapping studies
epitope fragmentation
modelling approach
steric hindrance
Thyroid Peroxidase
2015-12-01 16:01:29
Figure
https://plos.figshare.com/articles/figure/_Mapping_epitopes_onto_the_cis_TPO_dimer_/1615848
<p><b>(A)</b> Epitopes and residues identified in various studies as constituting immunodominant regions IDR-A (blue) and IDR-B (pink); <b>(B)</b> Lumen-facing side of MPO-like domain; <b>(C)</b> Close-up shows that much of the two immunodominant regions are on the lumen-facing surface of the MPO-like domain near the dimer interface, particularly IDR-B; <b>(D)</b> Membrane-facing side of TPO containing the heme (orange) cavity.</p>