10.1371/journal.pone.0142615.g004 Sarah N. Le Sarah N. Le Benjamin T. Porebski Benjamin T. Porebski Julia McCoey Julia McCoey James Fodor James Fodor Blake Riley Blake Riley Marlena Godlewska Marlena Godlewska Monika Góra Monika Góra Barbara Czarnocka Barbara Czarnocka J Paul Banga J Paul Banga David E. Hoke David E. Hoke Itamar Kass Itamar Kass Ashley M. Buckle Ashley M. Buckle Mapping epitopes onto the cis TPO dimer. Public Library of Science 2015 Autoantigenicity Thyroid peroxidase TPO structure Thyroid hormones apical membrane TPO dimer dimer organisation immunodominant regions sequence features 20 years surface regions dimer interface domain rearrangements Oligomeric State mpo enzyme function Epitope mapping studies epitope fragmentation modelling approach steric hindrance Thyroid Peroxidase 2015-12-01 16:01:29 Figure https://plos.figshare.com/articles/figure/_Mapping_epitopes_onto_the_cis_TPO_dimer_/1615848 <p><b>(A)</b> Epitopes and residues identified in various studies as constituting immunodominant regions IDR-A (blue) and IDR-B (pink); <b>(B)</b> Lumen-facing side of MPO-like domain; <b>(C)</b> Close-up shows that much of the two immunodominant regions are on the lumen-facing surface of the MPO-like domain near the dimer interface, particularly IDR-B; <b>(D)</b> Membrane-facing side of TPO containing the heme (orange) cavity.</p>