Kluba, Malgorzata Engelborghs, Yves Hofkens, Johan Mizuno, Hideaki Threonine phosphorylation at JM regions influences the monomer–dimer equilibrium of EGF-bound EGFR. <p>(A-D) Time traces of the diffusion coefficient of the EGFR with JM region threonine residue mutations; phosphodeficient mutant, EGFR<sup>T654/669A</sup> (A), three phosphomimic mutants, EGFR<sup>T654/669E</sup> (B), EGFR<sup>T654E</sup> (C), and EGFR<sup>T669E</sup> (D). (E) EGF (Alexa647-labeled, 0.17 μM; magenta) binding to EGFR<sup>T654/669E</sup> (green) expressing cell. The right panel shows the merged image. Scale bars represent 10 μm.</p> EGFR dimer formation;receptor monomerization;monomeric state;feedback loop;pkd;epidermal growth factor receptor;protein kinase D;EGFR Signaling Dimerization;feedback mechanism;juxtamembrane threonine residues;raster image correlation spectroscopy;Signal transduction;dimerization state;oscillatory behavior;Receptor Dimerization;2.5 min 2015-10-14
    https://plos.figshare.com/articles/figure/_Threonine_phosphorylation_at_JM_regions_influences_the_monomer_8211_dimer_equilibrium_of_EGF_bound_EGFR_/1575194
10.1371/journal.pone.0139971.g004