10.1371/journal.pone.0139238.g007 Mukesh Kumar Yadav Mukesh Kumar Yadav Yoon Young Go Yoon Young Go Sung-Won Chae Sung-Won Chae Jae-Jun Song Jae-Jun Song Confocal microscopic images of <i>Streptococcus pneumoniae</i> D39 biofilms grown with and without pyrimidinedione. Public Library of Science 2015 Small Molecule DAM Inhibitor cck Streptococcus pneumoniae D 39 pneumococcal biofilm growth novel antimicrobial compounds gene expression planktonic cell growth host defense systems microarray analysis gene expression profiles scanning electron microscopy analysis amc molecule Dam inhibitor study gene expression middle ear epithelium cell line mssa extracellular polysaccharide matrix biofilm formation exhibit eukaryotic cell toxicity Staphylococcus epidermidis biofilm growth scanning electron microscopy confocal microscopy analysis microtiter plate assay Vitro Streptococcus pneumoniae DNA adenine methyltransferase mrsa pyrimidinedione Streptococcus pneumoniae biofilm formation Disrupts Streptococcus pneumoniae Biofilm Growth 2015-10-02 03:23:33 Figure https://plos.figshare.com/articles/figure/_Confocal_microscopic_images_of_Streptococcus_pneumoniae_D39_biofilms_grown_with_and_without_pyrimidinedione_/1562987 <p><b>(</b>A & B) Representative confocal images of a control sample. The biofilms in the control sample were thick with an organized 3-dimesional structure. <b>(</b>C & D) Representative confocal images of biofilms grown with 7 μM/ml pyrimidinedione. The pyrimidinedione-grown biofilms were thin and disorganized, with clumps of cells attached to the bottom of plate.</p>