Expression of wildtype growth plate zone gene signatures in <i>ColX</i><sup><i>N617K</i></sup>, <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, and <i>C/X</i> hypertrophic zones.
Trevor L. Cameron
Katrina M. Bell
Irma L. Gresshoff
Lisa Sampurno
Lorna Mullan
Joerg Ermann
Laurie H. Glimcher
Raymond P. Boot-Handford
John F. Bateman
10.1371/journal.pgen.1005505.g006
https://plos.figshare.com/articles/figure/_Expression_of_wildtype_growth_plate_zone_gene_signatures_in_ColX_N617K_Xbp1_Cart_916_Ex2_and_C_X_hypertrophic_zones_/1545165
<p>Heatmaps depicting the relative fold difference (log fold change) of microarray probes representing <i>(A)</i> 773 wildtype (<i>Wt</i>) proliferative zone signature genes and <i>(B)</i> 510 <i>Wt</i> hypertrophic zone signature genes following the comparison of <i>C/X</i> versus <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, <i>ColX</i><sup><i>N617K</i></sup> versus <i>Wt</i>, and <i>Xbp1</i><sup><i>CartΔEx2</i></sup> versus <i>Wt</i> hypertrophic zones; N = 3. For both heatmaps, each <i>Wt</i> growth plate zone signature gene is represented by a single bar, colour-coded according to relative expression as indicated, with up-regulated probes coloured yellow, and down-regulated probes coloured red.</p>
2015-09-15 03:14:21
Disease Schmid metaphyseal chondrodysplasia
canonical ER stress sensors
XBP
exogenous misfolding protein
chop
perk
hypertrophic zone collagen
GADD
chondrocyte differentiation
hypertrophic chondrocytes
upr
atf
Col 10a Mouse models phenocopying MCDS
pathology
ColXN 617K
growth plate cartilage hypertrophic zone expansion
hypertrophic zone cartilage
hypertrophic zone expansion
ire
runx