Expression of wildtype growth plate zone gene signatures in <i>ColX</i><sup><i>N617K</i></sup>, <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, and <i>C/X</i> hypertrophic zones. Trevor L. Cameron Katrina M. Bell Irma L. Gresshoff Lisa Sampurno Lorna Mullan Joerg Ermann Laurie H. Glimcher Raymond P. Boot-Handford John F. Bateman 10.1371/journal.pgen.1005505.g006 https://plos.figshare.com/articles/figure/_Expression_of_wildtype_growth_plate_zone_gene_signatures_in_ColX_N617K_Xbp1_Cart_916_Ex2_and_C_X_hypertrophic_zones_/1545165 <p>Heatmaps depicting the relative fold difference (log fold change) of microarray probes representing <i>(A)</i> 773 wildtype (<i>Wt</i>) proliferative zone signature genes and <i>(B)</i> 510 <i>Wt</i> hypertrophic zone signature genes following the comparison of <i>C/X</i> versus <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, <i>ColX</i><sup><i>N617K</i></sup> versus <i>Wt</i>, and <i>Xbp1</i><sup><i>CartΔEx2</i></sup> versus <i>Wt</i> hypertrophic zones; N = 3. For both heatmaps, each <i>Wt</i> growth plate zone signature gene is represented by a single bar, colour-coded according to relative expression as indicated, with up-regulated probes coloured yellow, and down-regulated probes coloured red.</p> 2015-09-15 03:14:21 Disease Schmid metaphyseal chondrodysplasia canonical ER stress sensors XBP exogenous misfolding protein chop perk hypertrophic zone collagen GADD chondrocyte differentiation hypertrophic chondrocytes upr atf Col 10a Mouse models phenocopying MCDS pathology ColXN 617K growth plate cartilage hypertrophic zone expansion hypertrophic zone cartilage hypertrophic zone expansion ire runx