10.1371/journal.pgen.1005505.g004
Trevor L. Cameron
Trevor
L. Cameron
Katrina M. Bell
Katrina
M. Bell
Irma L. Gresshoff
Irma
L. Gresshoff
Lisa Sampurno
Lisa
Sampurno
Lorna Mullan
Lorna
Mullan
Joerg Ermann
Joerg
Ermann
Laurie H. Glimcher
Laurie
H. Glimcher
Raymond P. Boot-Handford
Raymond
P. Boot-Handford
John F. Bateman
John F.
Bateman
Quantitative PCR of mutant and wildtype hypertrophic zones.
Public Library of Science
2015
Disease Schmid metaphyseal chondrodysplasia
canonical ER stress sensors
XBP
exogenous misfolding protein
chop
perk
hypertrophic zone collagen
GADD
chondrocyte differentiation
hypertrophic chondrocytes
upr
atf
Col 10a Mouse models phenocopying MCDS
pathology
ColXN 617K
growth plate cartilage hypertrophic zone expansion
hypertrophic zone cartilage
hypertrophic zone expansion
ire
runx
2015-09-15 03:14:21
Figure
https://plos.figshare.com/articles/figure/_Quantitative_PCR_of_mutant_and_wildtype_hypertrophic_zones_/1545161
<p>qPCR with primers specific for <i>(A) Agc1</i>, <i>(B) Ctgf</i>, <i>(C) Matn1</i>, <i>(D) Creld2</i>, <i>(E) Derl3</i>, <i>(F) Ero1l</i>, <i>(G) Fgf21</i>, <i>(H) Steap1</i>, and <i>(I) p58IPK</i> on cDNA derived from <i>Wt</i>, <i>Xbp1</i><sup><i>CartΔEx2</i></sup>, <i>ColX</i><sup><i>N617K</i></sup> and <i>C/X</i> hypertrophic zone aRNA. Plots depict mean fold differences with standard deviation from the mean, N = 3, statistical significance was determined using Student’s <i>t</i> test, ** <i>p</i> < 0.01, *** <i>p</i> < 0.001, **** <i>p</i> < 0.0001.</p>