%0 Figure %A Makino, Yasukazu %A Konoshita, Tadashi %A Omori, Atsuhito %A Maegawa, Nobuhiro %A Nakaya, Takahiro %A Ichikawa, Mai %A Yamamoto, Katsushi %A Wakahara, Shigeyuki %A Ishizuka, Tamotsu %A Onoe, Tamehito %A Nakamura, Hiroyuki %D 2015 %T Genetic variants of REN and their gene expressions in renal tissue. %U https://plos.figshare.com/articles/figure/_Genetic_variants_of_REN_and_their_gene_expressions_in_renal_tissue_/1541299 %R 10.1371/journal.pone.0137469.g003 %2 https://plos.figshare.com/ndownloader/files/2261091 %K 5312 C allele %K vs %K plasma renin activity %K sbp %K pcr %K gapdh %K rna %K se %K ren %K transcription activity levels %K Distal Enhancer Region %K cc %K ct %K 5312 T allele %K tt %K renin gene %K Human Renin Gene Affects Renin Expression BackgroundThe %K enhancer region %K expression %X

mRNA for REN from human renal tissue was measured and compared among genotypes of C-5312T at the distal enhancer site. The values for genetic expression are expressed as logarithmically transformed values of their relative ratio to GAPDH (10−3). Columns and bars show the means and standard errors. The values were as follow (means ± SE): CC, 0.016 ± 0.005; CT, 0.047 ± 0.021 (p = 0.41 vs. CC); TT, 0.198 ± 0.194 (p = 0.011 vs. CC, p < 0.031 vs. CT) (A). The results of the comparisons between genotypes were as follows: CC and CT/TT (0.067 ± 0.031), p = 0.177 (B); CC/CT (0.033 ± 0.012) and TT, p = 0.015 (C).

%I PLOS ONE