Residues involved in binding mapped onto HEPN crystal structure. Xinlu Li Marie Ménade Guennadi Kozlov Zheping Hu Zheng Dai Peter S. McPherson Bernard Brais Kalle Gehring 10.1371/journal.pone.0137298.g006 https://plos.figshare.com/articles/figure/_Residues_involved_in_binding_mapped_onto_HEPN_crystal_structure_/1541284 <p>Residues that produced chemical shift changes during the NMR titrations with DMSO (A), AN670 (B), AK968 (C) and AN652 (D) were mapped onto the HEPN crystal structure. In each structure, DMSO-binding residues are labeled in <i>blue</i> and additional residues binding to the hit candidates are labeled in <i>red</i>.</p> 2015-09-14 02:46:08 cell culture studies neuron binding neurodegenerative disease autosomal recessive spastic ataxia ARSACS sacsin protein quality control nucleotide HEPN domain FP competition assays