10.1371/journal.pone.0134209.g002 Charles S. Berenson Charles S. Berenson Ragina L. Kruzel Ragina L. Kruzel Catherine T. Wrona Catherine T. Wrona Manoj J. Mammen Manoj J. Mammen Sanjay Sethi Sanjay Sethi Association of TLR9 SNPs and bacterial induction of COPD ex-smoker alveolar macrophage IL-8. Public Library of Science 2015 1237C snp Impaired Innate COPD Alveolar Macrophage Responses alveolar macrophage responses nontypeable H dna polymerase chain reaction fev nucleotide polymorphism expression nucleotide polymorphisms tlr COPD alveolar macrophage responses il nontypeable Haemophilus influenzae 2015-09-11 04:01:55 Figure https://plos.figshare.com/articles/figure/_Association_of_TLR9_SNPs_and_bacterial_induction_of_COPD_ex_smoker_alveolar_macrophage_IL_8_/1540572 <p>Supernatant IL-8 concentrations of alveolar macrophages, obtained from ex-smokers with COPD, incubated with nontypeable <i>Haemophilus influenzae</i> 11P6H1 (Panels A), <i>Moraxella catarrhalis</i> 6P29B1 (Panels B) and <i>Streptococcus pneumoniae</i> 25P55S1 (Panels C), were measured at 6 hours. Analysis is shown for TLR9 wildtype (dark shading) compared with TLR9 (T1237C) (light shading) on left panels. Analysis for TLR9 wildtype (dark shading) compared with TLR9 (T1486C) (striped shading) is shown in right panels. Results are shown as box plots for each group. Each box encompasses the 25<sup>th</sup> to 75<sup>th</sup> interquartile range, with the horizontal line in each box representing median values. Each vertical bar encompasses the 10<sup>th</sup> to 90<sup>th</sup> percentile ranges. Values correspond with data given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134209#pone.0134209.t006" target="_blank">Table 6</a>.</p>