10.1371/journal.pgen.1005434.g006 Michael S. Behnke Michael S. Behnke Asis Khan Asis Khan Elvin J. Lauron Elvin J. Lauron John R. Jimah John R. Jimah Qiuling Wang Qiuling Wang Niraj H. Tolia Niraj H. Tolia L. David Sibley L. David Sibley Codons under positive diversifying selection encode amino acid residues at the ROP5B<sub>I</sub> /IRGa6 interface. Public Library of Science 2015 type 8 TgCtBr 5 type 1 parasites host immunity factors xii South American strains virulence factor accounting Virulence factors Rhoptry Proteins ROP 5 ROP 5 North American type 2 South American type 10 VAND strain qtl ROP 18 Toxoplasma gondii Toxoplasma gondii ROP 18 function ROP 5 locus type 10 strains Major Murine Virulence Factors ROP 18 knockouts Quantitative trait locus type 4 TgCtBr 18 strains 2015-08-20 03:46:14 Figure https://plos.figshare.com/articles/figure/_Codons_under_positive_diversifying_selection_encode_amino_acid_residues_at_the_ROP5B_I_IRGa6_interface_/1515760 <p>(A) Structure of <i>T</i>. <i>gondii</i> ROP5B<sub>I</sub> (grey) bound to murine Irga6 (tan) showing amino acid residues under positive diversifying selection (red), ROP5B<sub>I</sub> residues at the ROP5B<sub>I</sub> /Irga6 interface (blue), and residues that are under positive diversifying selection and at the interface (purple). (B) Both panels are a rotation of 60° about the x-axis with respect to A, showing ROP5B<sub>I</sub> with Irga6 removed for clarity. The color scheme is as in A. Bottom panel is a surface representation showing the overlap in surface residues. The top panel shows the position of all amino acid residues under positive diversifying selection.</p>