Du, Huijing Nie, Qing R. Holmes, William A schematic illustration of the crypt’s structure and cell lineage classification. <p><b><i>Panel A)</i></b> A cartoon of the intestinal crypt and the relative location of cells of different lineages. <b><i>Panel B)</i></b> A diagram of cell lineages. Stem cells give rise to terminally differentiated enterocytes, Goblet and Paneth cells, depending jointly on Wnt concentration as well as Notch expression of that cell’s neighbors. Only Paneth cells undergo apoptosis, since Goblet cells and enterocytes naturally undergo anoikis upon reaching the top of the crypt.</p> Growth Promotes Robust Intestinal Crypt Structure;diffusible signals;Paneth cell;exogenous niche;alternative view;Negative Regulation;exogenous gradient;results show;Paneth cells;bmp;niche expansion;Wnt signals;crypt fission;regulation;crypt homeostasis;niche dynamics;Wnt Mediated Expansion 2015-08-19
    https://plos.figshare.com/articles/figure/_A_schematic_illustration_of_the_crypt_8217_s_structure_and_cell_lineage_classification_/1513909
10.1371/journal.pcbi.1004285.g001