A) Visant plot of top 1500 gene connections in 22q11DS Purple module, which is significantly associated with a psychotic disorder (<i>p</i> = .03) and positive symptoms (<i>p</i> = 5.0e-8).
Maria Jalbrzikowski
Maria T. Lazaro
Fuying Gao
Alden Huang
Carolyn Chow
Daniel H. Geschwind
Giovanni Coppola
Carrie E. Bearden
10.1371/journal.pone.0132542.g005
https://plos.figshare.com/articles/figure/_A_Visant_plot_of_top_1500_gene_connections_in_22q11DS_Purple_module_which_is_significantly_associated_with_a_psychotic_disorder_p_03_and_positive_symptoms_p_5_0e_8_/1491720
<p>Genes that are the most strongly connected are listed in a larger font than less connected genes. Genes found in the Purple module that overlap with genes in the Salmon module, which was validated in a set of antipsychotic naive schizophrenia patients module [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132542#pone.0132542.ref051" target="_blank">51</a>] are highlighted in red. B) Visant plot of top 1500 gene connections in 22q11DS Royal Blue module, which is significantly associated with an ASD diagnosis. Genes that are most strongly connected are listed in larger font than other, less connected genes. Genes found in the Royal Blue module that overlap with genes in M12 autism-related brain expressed module [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132542#pone.0132542.ref052" target="_blank">52</a>] are highlighted in red.</p>
2015-07-22 03:02:56
idiopathic psychosis
expression changes
antipsychotic medication use
risk factors
22 q 11.2 Deletion Syndrome
response pathways
WGCNA analyses
ht
transcriptional regulation
idiopathic ASD.ConclusionThese findings
Functional Pathways Related
brain tissue
22 q 11DS patients
gene
idiopathic schizophrenia
22 q 11DS
peripheral blood
deletion characteristics
22 q 11DS individuals
pathways dysregulated
22 q 11DS carriers
module
Transcriptome Profiling
3 Mb deletion
data mining techniques
deletion breakpoints
de
Genomic Analyses
phenotypic variation
aCGH array
spectrum disorders
transcriptional changes