A) Visant plot of top 1500 gene connections in 22q11DS Purple module, which is significantly associated with a psychotic disorder (<i>p</i> = .03) and positive symptoms (<i>p</i> = 5.0e-8). Maria Jalbrzikowski Maria T. Lazaro Fuying Gao Alden Huang Carolyn Chow Daniel H. Geschwind Giovanni Coppola Carrie E. Bearden 10.1371/journal.pone.0132542.g005 https://plos.figshare.com/articles/figure/_A_Visant_plot_of_top_1500_gene_connections_in_22q11DS_Purple_module_which_is_significantly_associated_with_a_psychotic_disorder_p_03_and_positive_symptoms_p_5_0e_8_/1491720 <p>Genes that are the most strongly connected are listed in a larger font than less connected genes. Genes found in the Purple module that overlap with genes in the Salmon module, which was validated in a set of antipsychotic naive schizophrenia patients module [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132542#pone.0132542.ref051" target="_blank">51</a>] are highlighted in red. B) Visant plot of top 1500 gene connections in 22q11DS Royal Blue module, which is significantly associated with an ASD diagnosis. Genes that are most strongly connected are listed in larger font than other, less connected genes. Genes found in the Royal Blue module that overlap with genes in M12 autism-related brain expressed module [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132542#pone.0132542.ref052" target="_blank">52</a>] are highlighted in red.</p> 2015-07-22 03:02:56 idiopathic psychosis expression changes antipsychotic medication use risk factors 22 q 11.2 Deletion Syndrome response pathways WGCNA analyses ht transcriptional regulation idiopathic ASD.ConclusionThese findings Functional Pathways Related brain tissue 22 q 11DS patients gene idiopathic schizophrenia 22 q 11DS peripheral blood deletion characteristics 22 q 11DS individuals pathways dysregulated 22 q 11DS carriers module Transcriptome Profiling 3 Mb deletion data mining techniques deletion breakpoints de Genomic Analyses phenotypic variation aCGH array spectrum disorders transcriptional changes