Jalbrzikowski, Maria T. Lazaro, Maria Gao, Fuying Huang, Alden Chow, Carolyn H. Geschwind, Daniel Coppola, Giovanni E. Bearden, Carrie Network construction of co-expressed genes in relation to psychosis and autism spectrum disorders in 22q11DS. <p>A) Dendogram of modules identified through Weighted Gene Co-expression Analysis, created through linkage hierarchical clustering of genes. B) Module-Trait relationships for age, gender, psychotic disorder diagnosis, autism spectrum disorder diagnosis, and positive symptoms, as measured by the SIPs. Numbers shown represent Pearson correlations between the modules and traits. P-values are in parentheses. Numbers on the color bar refer to the strength of the correlation in the table (red = 1, green = -1).</p> idiopathic psychosis;expression changes;antipsychotic medication use;risk factors;22 q 11.2 Deletion Syndrome;response pathways;WGCNA analyses;ht;transcriptional regulation;idiopathic ASD.ConclusionThese findings;Functional Pathways Related;brain tissue;22 q 11DS patients;gene;idiopathic schizophrenia;22 q 11DS;peripheral blood;deletion characteristics;22 q 11DS individuals;pathways dysregulated;22 q 11DS carriers;module;Transcriptome Profiling;3 Mb deletion;data mining techniques;deletion breakpoints;de;Genomic Analyses;phenotypic variation;aCGH array;spectrum disorders;transcriptional changes 2015-07-22
    https://plos.figshare.com/articles/figure/_Network_construction_of_co_expressed_genes_in_relation_to_psychosis_and_autism_spectrum_disorders_in_22q11DS_/1491718
10.1371/journal.pone.0132542.g004