The effect of age on the number of heteroplasmies in the unrelated SardiNIA sequencing project participants. Jun Ding Carlo Sidore Thomas J. Butler Mary Kate Wing Yong Qian Osorio Meirelles Fabio Busonero Lam C. Tsoi Andrea Maschio Andrea Angius Hyun Min Kang Ramaiah Nagaraja Francesco Cucca Gonçalo R. Abecasis David Schlessinger 10.1371/journal.pgen.1005306.g005 https://plos.figshare.com/articles/figure/_The_effect_of_age_on_the_number_of_heteroplasmies_in_the_unrelated_SardiNIA_sequencing_project_participants_/1482880 <p>The number of heteroplasmies increases with age with different (colored) minor allele fraction (MAF) thresholds. Each line plots the expected number of heteroplasmies based on the Poisson loglinear model against age at an MAF threshold; while the points represent the observed mean number of heteroplasmies in each age group (<40, 40–50, 50–60, 60–70, 70–80, >80).</p> 2015-07-14 03:37:42 association body mass index heteroplasmie Assessing Mitochondrial DNA Variation heteroplasmy homoplasmie mtDNA copy numbers copy number mtDNA copy number sequencing error rates Tailored Sequencing Analysis Tools DNA sequencing variant