%0 Generic %A Zhang, Yulian %A Lin, Cuiru %A Zhang, Linlin %A Cui, Yuanwu %A Gu, Yun %A Guo, Jiakui %A Wu, Di %A Li, Qiang %A Song, Wanshan %D 2015 %T Linear mixed effect model estimates of fixed effects (ADAS-cog, MMSE, ADL, NPI). %U https://plos.figshare.com/articles/dataset/_Linear_mixed_effect_model_estimates_of_fixed_effects_ADAS_cog_MMSE_ADL_NPI_/1449458 %R 10.1371/journal.pone.0130353.t003 %2 https://plos.figshare.com/ndownloader/files/2113080 %K npi %K Chinese Herbal Formula %K term efficacy.ConclusionsOur study %K score %K YHD group %K adl %K Randomized Controlled Trial ObjectivesTo %K formula YHD %K formula Yishen Huazhuo decoction %K DH group %K AD meeting %K donepezil hydrochloride %K mmse %K Cognitive Improvement %X

* indicates the main effects after dropping the insignificant group x time interaction.

Time × group interaction effect was observed in the scores of MMSE (F107.776 = 3.251, p = 0.025). The scores in both groups increased in week 12 and 24, by 1.72±2.59 in YHD group and 1.27±2.23 in DH group, but there is no significant difference between groups during the 24-week treatment. Compared with week-24, the scores of ADAS-cog in the follow up in week 48 showed a decrease of 0.40±1.63 in YHD group, but significantly less than the decrease of 1.38±2.68 in DH group (p<0.05).

Linear mixed effect model estimates of fixed effects (ADAS-cog, MMSE, ADL, NPI).

%I PLOS ONE