10.1371/journal.pone.0128546.g003
Jiro Ikeda
Jiro
Ikeda
Toshihiro Ichiki
Toshihiro
Ichiki
Yusuke Takahara
Yusuke
Takahara
Hiroshi Kojima
Hiroshi
Kojima
Chikahiro Sankoda
Chikahiro
Sankoda
Shiro Kitamoto
Shiro
Kitamoto
Tomotake Tokunou
Tomotake
Tokunou
Kenji Sunagawa
Kenji
Sunagawa
Reversion of the anti-ER stress and anti-apoptotic effects of pioglitazone by GW9662.
Public Library of Science
2015
ER stress
chop
perk
raw
jnk
Western Blot analysis
scd
type 2 diabetes
agonist
expression
murine macrophage cell line
ppar
gw
Macrophages BackgroundClinical trials
ER stress marker
2015-06-10 03:21:56
Figure
https://plos.figshare.com/articles/figure/_Reversion_of_the_anti_ER_stress_and_anti_apoptotic_effects_of_pioglitazone_by_GW9662_/1444927
<p>RAW264.7 cells were pretreated with GW9662 (1, 5, 10 μmol/L) for 1 hour and incubated with pioglitazone (10 μmol/L) for 6 hours. Then, cells were stimulated with palmitate (400 μmol/L) for 16 hours. Western blot analyses for phospho (P)-PERK (A), CHOP (B), phospho (P)-JNK (C), cleaved caspase-3 (D) were performed. The bar graphs indicate the ratio of P-PERK to PERK, CHOP to α-tubulin, P-JNK to JNK, and cleaved caspase-3 to α-tubulin, respectively. *P<0.05, ** P<0.01 vs control (palmitate (-), Pioglitazone (-) and GW9662 (-)), #P<0.05 vs palmitate, †P<0.05, ††P<0.01 vs Palmitate+Pioglitazone. n = 4.</p>