10.1371/journal.pone.0129655.g001 Xiaoxiao Jiang Xiaoxiao Jiang Yaping Chen Yaping Chen Haitao Zhu Haitao Zhu Bo Wang Bo Wang Ping Qu Ping Qu Renfu Chen Renfu Chen Xiaoqing Sun Xiaoqing Sun H&E-stained paraffin-embedded rat bladder sections. Public Library of Science 2015 sodium tanshinone IIA sulfonate rat PBOO model tgf sham operation group bladder fibrosis collagen III expression phosphorylated Smad 2 PBOO rats intraperitoneal vehicle injection transcriptase polymerase chain reaction ameliorate bladder fibrosis PBOO operation sma 8 weeks post PBOO Bladder Outlet Obstruction Partial Bladder Outlet Obstruction STS treatment group Sodium Tanshinone IIA Sulfonate Ameliorates Bladder Fibrosis STS ameliorates bladder fibrosis pathway activation 2015-06-10 03:22:43 Figure https://plos.figshare.com/articles/figure/_H_amp_E_stained_paraffin_embedded_rat_bladder_sections_/1444925 <p>In PBOO rats, significant detrusor muscle hypertrophy, alongside a progressive increase in fibrosis (dyed pale pink, blue arrow) and loss of normal muscle tissue (dyed purple or red, black arrow)architecture was observable at 4 and 8 weeks of PBOO. Fibrosis was inhibited in the STS group at (a) week 4 in Sham group, (b) week 4 after PBOO, (c) week 4 after PBOO+STS treatment, (d) week 8 after Sham group, (e) week 8 after PBOO, and(f) week 8 after PBOO+STS treatment. The PBOO and STS groups show detrusor hypertrophy and collagen deposition. Original magnifications, ×40.</p>