Gao, Dengfeng Hao, Guanghua Meng, Zhe Ning, Ning Yang, Guang Liu, Zhongwei Dong, Xin Niu, Xiaolin ERK signaling pathway in the effects of PPAR-γ agonist on Ang II-mediated KLF5 expression. <p>(A) VSMCs were subjected to ERK1/2 inhibitor PD098059 (1 μM) for 30min, followed by treatment of rosiglitazone (5 μM) for further 1 h, and finally stimulated with Ang II (0.1 mM) for 24 h. A representative western blot of KLF5 (upper panel), and data of mean ± S.E.M. of 3 experiments (bottom panel) were shown. (B) VSMCs were pretreated with rosiglitazone (5 μM) for 1h, and incubated with Ang II (0.1 μM) for 30 min, phosphorylated ERK1/2 were then detected by western blot. A representative western blot of ERK1/2 and p-ERK1/2, and data of mean ± S.E.M. of 3 experiments (bottom panel) were shown. Results are expressed as fold increase over control group. β-actin served as an internal control. (*<i>P<0</i>.<i>05</i> vs. control; #<i>P<0</i>.<i>05</i> vs. Ang II.)</p> growth response protein;Rat Vascular Smooth Muscle Cells Kr üppel factor;target gene cyclin D 1;gw;pkc;protein kinase C;KLF 5 expression;VSMC proliferation;rosiglitazone;ang;ppar;Cyclin D 1.;KLF 5;erk;mechanism;ii 2015-04-14
    https://plos.figshare.com/articles/figure/_ERK_signaling_pathway_in_the_effects_of_PPAR_947_agonist_on_Ang_II_mediated_KLF5_expression_/1379148
10.1371/journal.pone.0123724.g008