10.1371/journal.ppat.1002372
Thierry Fontaine
Thierry
Fontaine
Aurélie Delangle
Aurélie
Delangle
Catherine Simenel
Catherine
Simenel
Bernadette Coddeville
Bernadette
Coddeville
Sandra J. van Vliet
Sandra
J. van Vliet
Yvette van Kooyk
Yvette van
Kooyk
Silvia Bozza
Silvia
Bozza
Silvia Moretti
Silvia
Moretti
Flavio Schwarz
Flavio
Schwarz
Coline Trichot
Coline
Trichot
Markus Aebi
Markus
Aebi
Muriel Delepierre
Muriel
Delepierre
Carole Elbim
Carole
Elbim
Luigina Romani
Luigina
Romani
Jean-Paul Latgé
Jean-Paul
Latgé
Galactosaminogalactan, a New Immunosuppressive Polysaccharide of <em>Aspergillus fumigatus</em>
Public Library of Science
2011
immunosuppressive
polysaccharide
2011-11-10 00:25:09
Dataset
https://plos.figshare.com/articles/dataset/Galactosaminogalactan_a_New_Immunosuppressive_Polysaccharide_of_Aspergillus_fumigatus_/131509
<div><p>A new polysaccharide secreted by the human opportunistic fungal pathogen <em>Aspergillus fumigatus</em> has been characterized. Carbohydrate analysis using specific chemical degradations, mass spectrometry, <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance showed that this polysaccharide is a linear heterogeneous galactosaminogalactan composed of α1-4 linked galactose and α1-4 linked N-acetylgalactosamine residues where both monosacharides are randomly distributed and where the percentage of galactose per chain varied from 15 to 60%. This polysaccharide is antigenic and is recognized by a majority of the human population irrespectively of the occurrence of an <em>Aspergillus</em> infection. GalNAc oligosaccharides are an essential epitope of the galactosaminogalactan that explains the universal antibody reaction due to cross reactivity with other antigenic molecules containing GalNAc stretches such as the N-glycans of <em>Campylobacter jejuni</em>. The galactosaminogalactan has no protective effect during <em>Aspergillus</em> infections. Most importantly, the polysaccharide promotes fungal development in immunocompetent mice due to its immunosuppressive activity associated with disminished neutrophil infiltrates.</p> </div>