10.1371/journal.pgen.1004911.g006
Tobias Troost
Tobias
Troost
Markus Schneider
Markus
Schneider
Thomas Klein
Thomas
Klein
Consequences of loss of <i>Notch</i> pathway activity in <i>emc</i> mutant cells.
Public Library of Science
2015
Notch pathway
proneural genes
transcriptional feedback loop
bHLH protein Daughterless
proneural state
SOP selection
imaginal disc cells
Sensory Organ Precursor
proneural activity
inhibition model
organ precursor cell
pnc
2015-01-08 03:28:21
Figure
https://plos.figshare.com/articles/figure/_Consequences_of_loss_of_Notch_pathway_activity_in_emc_mutant_cells_/1286636
<p>(A–C) In <i>Psn<sup>C1</sup> emc<sup>pel</sup></i> double mutant discs, expression of <i>sca</i> is stronger and expands more than in <i>emc<sup>pel</sup></i> mutants. Moreover, most <i>sca</i> expressing cells express Hnt, indicating that they became SOPs (compare with Fig. 5C, D). (D–G) Analysis of null mutant <i>emc Psn</i> clones. Clones are labelled by the loss of RFP and outlined in some panels. A large clone in the notum is highlighted by the dashed line. The expression of Hnt in addition to <i>sca</i>-lacZ indicates that most cells of the clone became SOPs, with the exception of the region in the hinge highlighted with the arrow. The arrowhead points to the small anterior region, which is devoid of <i>sca</i>-lacZ and Hnt expression. (G) Magnification of the notal area highlighted with the arrow in (D–F). White scale bar 50µm; cyan scale bar: 10µm.</p>