10.1371/journal.pgen.1004916.g007
Christopher L. Baker
Christopher
L. Baker
Shimpei Kajita
Shimpei
Kajita
Michael Walker
Michael
Walker
Ruth L. Saxl
Ruth
L. Saxl
Narayanan Raghupathy
Narayanan
Raghupathy
Kwangbom Choi
Kwangbom
Choi
Petko M. Petkov
Petko
M. Petkov
Kenneth Paigen
Kenneth
Paigen
Model for the evolution of <i>Prdm9</i> alleles and hotspot erosion.
Public Library of Science
2015
PRDM 9 binding
hotspot
Prdm 9Cst allele
PRDM 9Cst binding
Meiotic Recombination Meiotic recombination
PRDM 9 Drives Evolutionary Erosion
Zinc Finger Protein
Prdm 9 allele
histone methyltransferase activity
PRDM 9 drives
dna
DSB repair mechanism
Mus musculus subspecies
M.m
Prdm 9Cst
2015-01-08 03:30:19
Figure
https://plos.figshare.com/articles/figure/_Model_for_the_evolution_of_Prdm9_alleles_and_hotspot_erosion_/1286608
<p>(A) Predicted timeline for the origin of <i>Prdm9</i> alleles based on SNP frequency found at hotspots comparing B6 and CAST to SPRET. PRDM9<sup>Cst</sup> hotspots show an increase in SNPs in the B6 background, suggesting this allele was active in a shared lineage between <i>M.m. castaneus</i> and <i>M.m. domesticus</i>. PRDM9<sup>Dom2</sup> hotspots do not have increased SNPs in the CAST background suggesting this allele was never active in <i>M.m. castaneus</i>. (B) The PRDM9/hotspot lifecycle. Evolutionary erosion driven by biased PRDM9 initiation of recombination decreases hotspot activity over time at many hotspots in parallel. Mutation of <i>Prdm9</i> creates a new binding domain subsequently shifting the genome-wide position of hotspots.</p>