10.1371/journal.pgen.1004916.g007 Christopher L. Baker Christopher L. Baker Shimpei Kajita Shimpei Kajita Michael Walker Michael Walker Ruth L. Saxl Ruth L. Saxl Narayanan Raghupathy Narayanan Raghupathy Kwangbom Choi Kwangbom Choi Petko M. Petkov Petko M. Petkov Kenneth Paigen Kenneth Paigen Model for the evolution of <i>Prdm9</i> alleles and hotspot erosion. Public Library of Science 2015 PRDM 9 binding hotspot Prdm 9Cst allele PRDM 9Cst binding Meiotic Recombination Meiotic recombination PRDM 9 Drives Evolutionary Erosion Zinc Finger Protein Prdm 9 allele histone methyltransferase activity PRDM 9 drives dna DSB repair mechanism Mus musculus subspecies M.m Prdm 9Cst 2015-01-08 03:30:19 Figure https://plos.figshare.com/articles/figure/_Model_for_the_evolution_of_Prdm9_alleles_and_hotspot_erosion_/1286608 <p>(A) Predicted timeline for the origin of <i>Prdm9</i> alleles based on SNP frequency found at hotspots comparing B6 and CAST to SPRET. PRDM9<sup>Cst</sup> hotspots show an increase in SNPs in the B6 background, suggesting this allele was active in a shared lineage between <i>M.m. castaneus</i> and <i>M.m. domesticus</i>. PRDM9<sup>Dom2</sup> hotspots do not have increased SNPs in the CAST background suggesting this allele was never active in <i>M.m. castaneus</i>. (B) The PRDM9/hotspot lifecycle. Evolutionary erosion driven by biased PRDM9 initiation of recombination decreases hotspot activity over time at many hotspots in parallel. Mutation of <i>Prdm9</i> creates a new binding domain subsequently shifting the genome-wide position of hotspots.</p>