%0 Figure %A L. Baker, Christopher %A Kajita, Shimpei %A Walker, Michael %A L. Saxl, Ruth %A Raghupathy, Narayanan %A Choi, Kwangbom %A M. Petkov, Petko %A Paigen, Kenneth %D 2015 %T The novel hotspot at chr1 40.6 Mb, activated by PRDM9Cst on the B6 haplotype, shows transmission distortion to the CAST haplotype. %U https://plos.figshare.com/articles/figure/_The_novel_hotspot_at_chr1_40_6_Mb_activated_by_PRDM9_Cst_on_the_B6_haplotype_shows_transmission_distortion_to_the_CAST_haplotype_/1286606 %R 10.1371/journal.pgen.1004916.g006 %2 https://plos.figshare.com/ndownloader/files/1863306 %K PRDM 9 binding %K hotspot %K Prdm 9Cst allele %K PRDM 9Cst binding %K Meiotic Recombination Meiotic recombination %K PRDM 9 Drives Evolutionary Erosion %K Zinc Finger Protein %K Prdm 9 allele %K histone methyltransferase activity %K PRDM 9 drives %K dna %K DSB repair mechanism %K Mus musculus subspecies %K M.m %K Prdm 9Cst %X

(A) PRDM9Cst motif aligned to the DNA sequence for both B6 and CAST haplotypes at the peak of PRDM9 ChIP-seq signal (B) PRDM9 and H3K4me3 coverage profile at chr1 40.6 Mb (black lines ā€“ SNP positions between B6 and CAST, black box ā€“ PRDM9Cst motif). (C) Proportion of mapped reads to each haplotype (unassigned reads lack informative SNPs). (D) Cumulative frequency of recombination crossovers at hotspot chr1 40.6 Mb (nā€Š=ā€Š19 mice). (E) Transmission distortion at hotspot chr1 40.6 Mb favors the CAST haplotype at the PRDM9 binding site.

%I PLOS Genetics