10.1371/journal.pone.0114542.g001 Takeru Shiraki Takeru Shiraki Takuma Aoyama Takuma Aoyama Chiharu Yokoyama Chiharu Yokoyama Yuka Hayakawa Yuka Hayakawa Toshiki Tanaka Toshiki Tanaka Kazuhiko Nishigaki Kazuhiko Nishigaki Tatsuya Sawamura Tatsuya Sawamura Shinya Minatoguchi Shinya Minatoguchi Laser Doppler blood flow analysis of WT and LOX-1 KO mice. Public Library of Science 2014 p 38 MAPK postoperative day 14. Immunohistochemical analysis WT mice macrophage infiltration KO mice show cell adhesion molecule ROS production assay ldl LDBF hindlimb ischemia model right hindlimb ischemia nf angiogenic factor VEGF histological capillary density NOX 2 expression vcam lox KO mice Western Blot analysis hif ad laser Doppler blood flowmetry 2014-12-16 02:50:09 Figure https://plos.figshare.com/articles/figure/_Laser_Doppler_blood_flow_analysis_of_WT_and_LOX_1_KO_mice_/1272397 <p>A: Representative images of LDBF just before and day 28 after surgery revealed hindlimb blood flow of the ischemic (R: right)/nonischemic (L: left) conditions in a supine position. B: Ischemic/nonischemic hindlimb blood flow ratio (mean±SD) were measured before (Pre), and on days 3, 7, 14, 21 and 28 after right femoral artery ligation. Results are expressed as the ratio of the ischemic hindlimb to nonischemic limb perfusion. <sup>★</sup>, P<0.05 vs. WT; <sup>★★</sup>, P<0.01 vs. WT; <sup>#</sup>, P<0.01 vs. Pre (before surgery), n = 25.</p>