10.1371/journal.pone.0111529.g004 Yi-Wei Liaw Yi-Wei Liaw Chi-Yu Lin Chi-Yu Lin Yu-Sheng Lai Yu-Sheng Lai Tzu-Chung Yang Tzu-Chung Yang Chau-Jong Wang Chau-Jong Wang Jacqueline Whang-Peng Jacqueline Whang-Peng Leroy F. Liu Leroy F. Liu Chia-Po Lin Chia-Po Lin Shin Nieh Shin Nieh Shao-Chun Lu Shao-Chun Lu Jaulang Hwang Jaulang Hwang Vaccination with Fc-CETP<sub>6</sub> attenuates high HFC diet-induced steatosis and NASH. Public Library of Science 2014 CETP epitope results show antigen delivery HFC diet novel CETP vaccine CETP activity atherosclerosi Pathological analyses nash b cells Cholesteryl Ester Transfer Protein rabbit IgG Fc domain Vaccine Targeted lipid accumulation plasma CETP activity CETP Alleviates High Fat 2014-12-08 02:47:12 Figure https://plos.figshare.com/articles/figure/_Vaccination_with_Fc_CETP_6_attenuates_high_HFC_diet_induced_steatosis_and_NASH_/1264144 <p>(A) Representative liver sections stained with H&E (magnification, x200). Liver section stained with H&E from control rabbits showing NASH characteristics, such as ballooning degeneration, infiltrating inflammatory cells and Mallory hyaline were observed in the control (magnification, x200). (B) Expression of RAM-11 (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP<sub>6</sub> rabbits. (C) Expression of NF-kB (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP<sub>6</sub> rabbits. (D) Expression of inflammation related genes in control rabbits (black bars) and Fc-CETP<sub>6</sub> rabbits (white bars). The bar graphs represent the average (C: control group n = 7; Fc-CETP<sub>6</sub> group n = 8) for each group with standard errors. Values are the mean ± SEM. *p<0.05; ***p<0.001 compared to the control.</p>