10.1371/journal.pone.0111529.g004
Yi-Wei Liaw
Yi-Wei
Liaw
Chi-Yu Lin
Chi-Yu
Lin
Yu-Sheng Lai
Yu-Sheng
Lai
Tzu-Chung Yang
Tzu-Chung
Yang
Chau-Jong Wang
Chau-Jong
Wang
Jacqueline Whang-Peng
Jacqueline
Whang-Peng
Leroy F. Liu
Leroy F.
Liu
Chia-Po Lin
Chia-Po
Lin
Shin Nieh
Shin
Nieh
Shao-Chun Lu
Shao-Chun
Lu
Jaulang Hwang
Jaulang
Hwang
Vaccination with Fc-CETP<sub>6</sub> attenuates high HFC diet-induced steatosis and NASH.
Public Library of Science
2014
CETP epitope
results show
antigen delivery
HFC diet
novel CETP vaccine
CETP activity
atherosclerosi
Pathological analyses
nash
b cells
Cholesteryl Ester Transfer Protein
rabbit IgG Fc domain
Vaccine Targeted
lipid accumulation
plasma CETP activity
CETP Alleviates High Fat
2014-12-08 02:47:12
Figure
https://plos.figshare.com/articles/figure/_Vaccination_with_Fc_CETP_6_attenuates_high_HFC_diet_induced_steatosis_and_NASH_/1264144
<p>(A) Representative liver sections stained with H&E (magnification, x200). Liver section stained with H&E from control rabbits showing NASH characteristics, such as ballooning degeneration, infiltrating inflammatory cells and Mallory hyaline were observed in the control (magnification, x200). (B) Expression of RAM-11 (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP<sub>6</sub> rabbits. (C) Expression of NF-kB (magnification, upper panel x100 and lower panel x400) of the liver from control and Fc-CETP<sub>6</sub> rabbits. (D) Expression of inflammation related genes in control rabbits (black bars) and Fc-CETP<sub>6</sub> rabbits (white bars). The bar graphs represent the average (C: control group n = 7; Fc-CETP<sub>6</sub> group n = 8) for each group with standard errors. Values are the mean ± SEM. *p<0.05; ***p<0.001 compared to the control.</p>