10.1371/journal.pcbi.1007998.g008 Atte S. A. Eskelinen Atte S. A. Eskelinen Petri Tanska Petri Tanska Cristina Florea Cristina Florea Gustavo A. Orozco Gustavo A. Orozco Petro Julkunen Petro Julkunen Alan J. Grodzinsky Alan J. Grodzinsky Rami K. Korhonen Rami K. Korhonen Simulation of degraded cartilage area. Public Library of Science 2020 cytokine diffusion-driven degradation cartilage degradation pathways biomechanical degradation bulk FCD loss FCD content stimulus Post-traumatic osteoarthritis PTOA cartilage explant degradation pro-inflammatory cytokine interleukin cartilage degradation tissue biomechanically-driven FCD loss mechanism lesion model 2020-06-25 18:03:46 Figure https://plos.figshare.com/articles/figure/Simulation_of_degraded_cartilage_area_/12567551 <p>Temporal estimations of degraded cartilage area with A) biochemical and combined biochemical and biomechanical degradation and B) biomechanical degradation. In these simulations, cartilage was considered”degraded” when FCD loss in elements was equal or greater than 20%. See <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007998#pcbi.1007998.s001" target="_blank">S1 Supplementary Material</a> (Subsection S2.4, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007998#pcbi.1007998.s006" target="_blank">S5 Fig</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007998#pcbi.1007998.s008" target="_blank">S1</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007998#pcbi.1007998.s011" target="_blank">S4</a> Animation) for animations showing the propagation of the degraded area over time.</p>