10.1371/journal.pmed.1003132.g004 Matthew Dapas Matthew Dapas Frederick T. J. Lin Frederick T. J. Lin Girish N. Nadkarni Girish N. Nadkarni Ryan Sisk Ryan Sisk Richard S. Legro Richard S. Legro Margrit Urbanek Margrit Urbanek M. Geoffrey Hayes M. Geoffrey Hayes Andrea Dunaif Andrea Dunaif Clustering of ungenotyped PCOS clustering cohort. Public Library of Science 2020 DENND 5C 893 PCOS cases IQCA PCOS genome-wide association study NIH sex hormone binding globulin GWAS subtype BMI insulin levels PRDM 263 PCOS cases BMPR FIGN SHBG KCNH analysis Background Polycystic ovary syndrome 1A 1B criteria polycystic ovary syndrome UNC CDH genotyped cohort IQR LH European ancestry PCOS cases KAZN 2020-06-23 17:24:32 Figure https://plos.figshare.com/articles/figure/Clustering_of_ungenotyped_PCOS_clustering_cohort_/12548171 <p>(a) Hierarchical clustering of 263 ungenotyped PCOS cases according to adjusted quantitative traits replicate reproductive (blue), metabolic (red), and unclassified (gray) clusters. Heatmap colors correspond to trait z-scores. (b) PCA plot of ungenotyped PCOS cases replicate results from genotyped cases. (a) Hierarchical clustering of 263 ungenotyped PCOS cases according to adjusted quantitative traits replicate reproductive (blue), metabolic (red), and indeterminate (gray) clusters. Heatmap colors correspond to trait z-scores. (b) PCA plot of ungenotyped PCOS cases replicate results from genotyped cases. BMI, body mass index; DHEAS, dehydroepiandrosterone sulfate; FSH, follicle-stimulating hormone; Glu0, fasting glucose; Ins0, fasting insulin; LH, luteinizing hormone; PC, principal component; PCA, principal component analysis; PCOS, polycystic ovary syndrome; SHBG, sex hormone binding globulin; T, testosterone.</p>