10.1371/journal.pmed.1003132.g004
Matthew Dapas
Matthew
Dapas
Frederick T. J. Lin
Frederick T. J.
Lin
Girish N. Nadkarni
Girish N.
Nadkarni
Ryan Sisk
Ryan
Sisk
Richard S. Legro
Richard S.
Legro
Margrit Urbanek
Margrit
Urbanek
M. Geoffrey Hayes
M. Geoffrey
Hayes
Andrea Dunaif
Andrea
Dunaif
Clustering of ungenotyped PCOS clustering cohort.
Public Library of Science
2020
DENND
5C
893 PCOS cases
IQCA
PCOS genome-wide association study
NIH
sex hormone binding globulin
GWAS
subtype
BMI
insulin levels
PRDM
263 PCOS cases
BMPR
FIGN
SHBG
KCNH
analysis Background Polycystic ovary syndrome
1A
1B
criteria
polycystic ovary syndrome
UNC
CDH
genotyped cohort
IQR
LH
European ancestry PCOS cases
KAZN
2020-06-23 17:24:32
Figure
https://plos.figshare.com/articles/figure/Clustering_of_ungenotyped_PCOS_clustering_cohort_/12548171
<p>(a) Hierarchical clustering of 263 ungenotyped PCOS cases according to adjusted quantitative traits replicate reproductive (blue), metabolic (red), and unclassified (gray) clusters. Heatmap colors correspond to trait z-scores. (b) PCA plot of ungenotyped PCOS cases replicate results from genotyped cases. (a) Hierarchical clustering of 263 ungenotyped PCOS cases according to adjusted quantitative traits replicate reproductive (blue), metabolic (red), and indeterminate (gray) clusters. Heatmap colors correspond to trait z-scores. (b) PCA plot of ungenotyped PCOS cases replicate results from genotyped cases. BMI, body mass index; DHEAS, dehydroepiandrosterone sulfate; FSH, follicle-stimulating hormone; Glu0, fasting glucose; Ins0, fasting insulin; LH, luteinizing hormone; PC, principal component; PCA, principal component analysis; PCOS, polycystic ovary syndrome; SHBG, sex hormone binding globulin; T, testosterone.</p>