%0 Figure %A Dapas, Matthew %A Lin, Frederick T. J. %A Nadkarni, Girish N. %A Sisk, Ryan %A Legro, Richard S. %A Urbanek, Margrit %A Hayes, M. Geoffrey %A Dunaif, Andrea %D 2020 %T Phenotypic trait distributions in reproductive and metabolic subtypes. %U https://plos.figshare.com/articles/figure/Phenotypic_trait_distributions_in_reproductive_and_metabolic_subtypes_/12548165 %R 10.1371/journal.pmed.1003132.g002 %2 https://plos.figshare.com/ndownloader/files/23358032 %K DENND %K 5C %K 893 PCOS cases %K IQCA %K PCOS genome-wide association study %K NIH %K sex hormone binding globulin %K GWAS %K subtype %K BMI %K insulin levels %K PRDM %K 263 PCOS cases %K BMPR %K FIGN %K SHBG %K KCNH %K analysis Background Polycystic ovary syndrome %K 1A %K 1B %K criteria %K polycystic ovary syndrome %K UNC %K CDH %K genotyped cohort %K IQR %K LH %K European ancestry PCOS cases %K KAZN %X

Median and IQRs are shown for normalized, adjusted quantitative trait distributions of genotyped PCOS cases with reproductive or metabolic subtype. The figure illustrates the traits for which the subtypes differ significantly with an asterisk (*Bonferroni adjusted Wilcoxon, Padj < 0.05): Ins0, BMI, Glu0, FSH, LH, and SHBG. BMI, body mass index; DHEAS, dehydroepiandrosterone sulfate; FSH, follicle-stimulating hormone; Glu0, fasting glucose; Ins0, fasting insulin; IQR, interquartile range; LH, luteinizing hormone; PCOS, polycystic ovary syndrome; SHBG, sex hormone binding globulin; T, testosterone.

%I PLOS Medicine