E. Drew, Janice J. Farquharson, Andrew Dieter Mayer, Claus F. Vase, Hollie J. Coates, Philip J. Steele, Robert A. Carey, Francis Multivariate discriminant analysis of the <i>UBE2D2</i> normalised gene GeXP hCellMarkerPlex data from human colon normal (white triangle) (n = 24), adenomatous polyp (grey triangle) (n = 17) and carcinoma (black triangle) (n = 19) tissues. <p>Information on the gene symbols on the biplot is available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113071#pone.0113071.s002" target="_blank">Table S2</a>. (A) Principal component analysis (PCA) biplot permits visualisation of inherent clustering patterns of individual tissue samples and associated gene expression levels. (B) Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) was applied to fit a 2-class supervised model maximising covariance and discriminating gene expression profiles associated with the different tissues sample types; the biplot shows scores and loadings as well as the regression coefficients best explaining each class ($M4.DA(N),$M4.DA(A),$M4.DA(C). (C) Rank of importance of cell marker genes within the OPLS-DA. (D) Matrix showing the associated misclassification rates.</p> report details application;1a;CCND;biopsy samples exhibit;actg;pcr;Individual gene targets;des;Identified gene signatures;Molecular Markers Distinguishing Colon Adenomatous Polyp;ezr;hdac;GenomeLab System multiplex gene expression assay;epithelial expression;disease initiation;nox;ms;vwf;gene expression multiplex assays;fsp;muc;col;9a;casp;slc;krt;carcinoma colon tissue;Predictive Gene Signatures;ntn;cdx;Carcinoma Cancers exhibit;pcna;adenomatous polyp;cnn;4a;archived tissue bank material;4GANLT;lgr 2014-11-25
    https://plos.figshare.com/articles/figure/_Multivariate_discriminant_analysis_of_the_UBE2D2_normalised_gene_GeXP_hCellMarkerPlex_data_from_human_colon_normal_white_triangle_n_24_adenomatous_polyp_grey_triangle_n_17_and_carcinoma_black_triangle_n_19_tissues_/1251669
10.1371/journal.pone.0113071.g001